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Principal Scientist – Preclinical Validation


Enara Bio’s purpose is to shine a light on unconventional T cell targets to develop cancer immunotherapies designed to provide lasting benefit for broad patient populations. Our proprietary EDAPT™ platform enables us to discover a novel and differentiated class of cancer-specific targets from the genomic dark matter, which we call Dark Antigens™. We are pioneering approaches to exploit these Dark Antigen targets with a range of immunotherapeutic modalities, including bispecific T-cell engagers, adoptive cell therapies and cancer vaccines.
Enara Bio was founded in 2016 and has been well funded to invest in the build out and growth of our R&D efforts and our fantastic team. The company is based in Oxford, UK

Job Summary

We are looking for an innovative and enthusiastic lab-based scientist to join our team, supporting our Preclinical Validation function within research, working throughout differing stages of our pipeline of dark antigen assets.

As a target validation principal scientist, you will work in close collaboration with discovery and immunology teams and have a good understanding of transcriptional biology, in order to reach the best-in-class dark antigens.

You will be expected to:

The role is an opportunity to help shape and expand the Target Validation pipeline capabilities within a rapidly growing organisation that will help steer our research from novel dark antigen discovery to investigational new drug (IND) applications and beyond.

Key Responsibilities

  • Demonstrate exceptional understanding of transcriptomics biology, specifically in the Dark genome field.
  • Understand principles of early target discovery and communicate effectively cross-functionally with Antigen Discovery pipeline process team members.
  • As an independent thinker, you will plan and perform experiments, interpret the data, troubleshoot, suggest next steps or alternative approaches.
  • Take an active role in building strong working collaborations with external partners, including academic centres and contract research organisations (CROs).
  • Utilise your subject matter expertise to mentor and develop members of your immediate team, as well as the wider research organisation.

Minimum Qualifications and Experience required

  • PhD level qualification or equivalent experience in biological or pharmacological science.
  • A deep level of experience gained (at least 7 years) in an industrial biopharmaceutical or academic setting, working in early target discovery and validation.
  • Strong knowledge in the field of dark genome and proteome, specifically on validation of non-canonical open reading frame (ORF) strategies.
  • Proven expertise in transcriptional biology techniques and data interpretation including RT-qPCR and RNA-seq.
  • Strong knowledge in functional genomics technologies, including generation of novel experimental systems, such as in vitro expression reporter models of translation and CRISPR/Cas9 screens.
  • Research experience in immunological disease setting.
  • A positive “can-do” attitude and a team player who proactively communicates and collaborates with all team members

  • Expertise in ribosome profiling and scRNA-seq is desirable.
  • Laboratory experience with mammalian cell culture desirable.
  • Experience of in vitro and in vivo models relevant to immuno-oncology.

Further information

The Enara Bio team is driven to make a meaningful difference for people affected by cancer. Our culture is defined by our behavioural ethos:

  • Act with unconditional positive regard and integrity
  • Support each other to grow and develop
  • Promote a collaborative, passionate and fun working environment
  • Innovate by discussing issues, data and ideas openly
  • Respect each other and value our diversity
  • Embrace our shared goals and take ownership of our journey

We offer a competitive salary, commensurate with qualifications and experience, and a benefits package including pension and health insurance.

Applicants should be able to demonstrate proof of the right to work in United Kingdom.
Enara Bio Limited is an equal opportunities employer.

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Job Reference: 1206732