IntroductionEnara Bio’s purpose is to shine a light on unconventional T cell targets to develop cancer immunotherapies designed to provide lasting benefit for broad patient populations. Our proprietary EDAPT™ platform enables us to discover a novel and differentiated class of cancer-specific targets from the genomic dark matter, which we call Dark Antigens™. We are pioneering approaches to exploit these Dark Antigen targets with a range of immunotherapeutic modalities, including bispecific T-cell engagers, adoptive cell therapies and cancer vaccines.
Enara Bio was founded in 2016 and has been well funded to invest in the build out and growth of our R&D efforts and our fantastic team. The company is based in Oxford, UK
Job SummaryWe are looking for an innovative and enthusiastic lab-based scientist to join our team, supporting our Preclinical Validation function within research, working throughout differing stages of our pipeline of dark antigen assets.
As a target validation principal scientist, you will work in close collaboration with discovery and immunology teams and have a good understanding of transcriptional biology, in order to reach the best-in-class dark antigens.
You will be expected to:The role is an opportunity to help shape and expand the Target Validation pipeline capabilities within a rapidly growing organisation that will help steer our research from novel dark antigen discovery to investigational new drug (IND) applications and beyond.
- Demonstrate exceptional understanding of transcriptomics biology, specifically in the Dark genome field.
- Understand principles of early target discovery and communicate effectively cross-functionally with Antigen Discovery pipeline process team members.
- As an independent thinker, you will plan and perform experiments, interpret the data, troubleshoot, suggest next steps or alternative approaches.
- Take an active role in building strong working collaborations with external partners, including academic centres and contract research organisations (CROs).
- Utilise your subject matter expertise to mentor and develop members of your immediate team, as well as the wider research organisation.
Minimum Qualifications and Experience required
- PhD level qualification or equivalent experience in biological or pharmacological science.
- A deep level of experience gained (at least 7 years) in an industrial biopharmaceutical or academic setting, working in early target discovery and validation.
- Strong knowledge in the field of dark genome and proteome, specifically on validation of non-canonical open reading frame (ORF) strategies.
- Proven expertise in transcriptional biology techniques and data interpretation including RT-qPCR and RNA-seq.
- Strong knowledge in functional genomics technologies, including generation of novel experimental systems, such as in vitro expression reporter models of translation and CRISPR/Cas9 screens.
- Research experience in immunological disease setting.
- A positive “can-do” attitude and a team player who proactively communicates and collaborates with all team members
- Expertise in ribosome profiling and scRNA-seq is desirable.
- Laboratory experience with mammalian cell culture desirable.
- Experience of in vitro and in vivo models relevant to immuno-oncology.
Further informationThe Enara Bio team is driven to make a meaningful difference for people affected by cancer. Our culture is defined by our behavioural ethos:
- Act with unconditional positive regard and integrity
- Support each other to grow and develop
- Promote a collaborative, passionate and fun working environment
- Innovate by discussing issues, data and ideas openly
- Respect each other and value our diversity
- Embrace our shared goals and take ownership of our journey
We offer a competitive salary, commensurate with qualifications and experience, and a benefits package including pension and health insurance.
Applicants should be able to demonstrate proof of the right to work in United Kingdom.
Enara Bio Limited is an equal opportunities employer.