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Scientist / Senior Scientist - Mass Spectrometry based Immunopeptidomics

Introduction

Enara Bio™ is a science-led company leveraging its proprietary discovery platforms to deliver targeted cancer immunotherapies designed to treat a broad patient population. Enara Bio is exploring the hidden depths of cancer and T-cell biology to discover and characterize novel, shared immunotherapy targets such as Dark Antigens™ and HLA-independent ligands. We are pioneering approaches to exploit these targets with a TCR-directed T-cell immunotherapy product pipeline.
Enara Bio was founded in 2016 and has been well funded to invest in the build out and growth of our R&D efforts and our fantastic team. The company is based in Oxford, UK.

Job Summary

Enara Bio has already established an expert team with first-in-class pipeline for identification of novel, previously undiscovered antigens for immunotherapies using MS-based proteomics and immunopeptidomics, we are now looking to build that expertise further.

We are looking for a highly motivated scientist to join our team who has a passion for mass spectrometry-based proteomics/immunopeptidomics applied to the exciting field of immuno-oncology. This role will help in the generation of proteomic and immunopeptidome datasets from primary tissue samples and cell lines using LC-MS/MS platforms. This role will make a major contribution in identifying and quantifying the most immunogenic antigens for incorporation into cell therapies to make a meaningful difference to patients suffering from cancer.

You will be expected to:

The successful candidate will also work closely with key external academic and non-academic partners in immunobiology, biochemistry and MS-based disciplines. Effective communication is essential to this role as you will be expected to communicate with our collaborators about our scientific research objectives.

Key Responsibilities

  • Provide technical leadership on various proteomics/ immunopeptidomics analysis and workflows, including peptide validation and target approaches for quantification of HLA peptides
  • Provide input for continuous development of MS-based proteomics/ immunopeptidomics methodologies
  • Provide technical support for MS-laboratory maintenance
  • Provide support with cell culture and Ab production from hybridomas
  • Analyse, interpret, and communicate data to ensure the highest standards of safety, quality, and reproducibility
  • Document experiments and findings according to high industry standards to support and enable filing of patents, publications, and regulatory documents
  • Closely interact with colleagues from multiple teams within the research organisation by effectively communicating your results and conclusions
  • Contribute to a vibrant and innovative working environment where improvements and new ideas are adopted and freely shared among the teams

Minimum Qualifications and Experience required

  • Ph.D. (or equivalent experience) in a relevant scientific discipline such as MS-based proteomics and/or immunopeptidomics
  • Proven working knowledge and in-depth technical expertise in LC-MS based proteomics/immunopeptidomics and related sample preparation
  • Hands-on experience in relevant biochemical techniques and development/maintenance of LC-MS (preferrable on Orbitraps)
Key skills
  • Proven experience in analysing proteomics/immunopeptidomics data
  • Cell culture experience desirable
  • Strong communicator, both written and verbal, with strong attention to detail
  • Excellent organisation skills and ability to monitor and track critical activities
  • Experience working in cross-functional teams
  • Self-motivated and enthusiastic team player
  • Proficient in all Microsoft Office systems, with an ability to familiarise with other IT systems as required

Closing date

Until filled

Further information

The Enara Bio team is driven to make a meaningful difference for people affected by cancer. Our culture is defined by our behavioural ethos:

  • Act with unconditional positive regard and integrity
  • Support each other to grow and develop
  • Promote a collaborative, passionate and fun working environment
  • Innovate by discussing issues, data, and ideas openly
  • Respect each other and value our diversity
  • Embrace our shard goals and take ownership of our journey

We offer a competitive salary, commensurate with qualifications and experience, and a benefits package including pension and health insurance.

Applicants should be able to demonstrate proof of the right to work in United Kingdom.
Enara Bio Limited is an equal opportunities employer.

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Job Reference: 495796