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Scientist / Senior Scientist - Preclinical Validation

Introduction

Enara Bio™ is a science-led company leveraging its proprietary discovery platforms to deliver targeted cancer immunotherapies designed to treat a broad patient population. Enara Bio is exploring the hidden depths of cancer and T-cell biology to discover and characterize novel, shared immunotherapy targets such as Dark Antigens™ and HLA-independent ligands. We are pioneering approaches to exploit these targets with a TCR-directed T-cell immunotherapy product pipeline.
Enara Bio was founded in 2016 and has been well funded to invest in the build out and growth of our R&D efforts and our fantastic team. The company is based in Oxford, UK.

Job Summary

We are looking for an innovative and enthusiastic lab-based scientist or senior scientist to join our team and support the establishment of a structured framework for immunotherapy target validation, across our pipeline of assets at differing stages of research and development.
You will have a good understanding of transcriptional biology, histological methods, and the ability to understand outputs of bioinformatic analysis.

You will be expected to:

The role is an opportunity to help shape a critical research function within a rapidly growing organisation by supporting the creation of target assessment data packages that will help steer our research from novel target discovery to investigational new drug (IND) applications and beyond.

Key Responsibilities

  • Support the implementation of new methods and technologies to establish a pipeline for validation of immunotherapy targets.
  • Contribute towards an innovative working environment by providing intellectual input across the pipeline and staying up to date with emerging technologies.
  • Transcriptional and histological assessment of novel targets across tissues and in vivo models (e.g.: RT-qPCR, RNA-Seq, RNAscope, Immunohistochemistry).
  • Plan, conduct, analyse and interpret results, both individually and as part of a team working with colleagues in bioinformatics to establish a robust data analysis pipeline.
  • Closely interact with colleagues from multiple teams within the research organisation by effectively communicating your results and conclusions.
  • Ensure data is analysed and reported to high industry standards to support future regulatory submissions (e.g. IND/IDEs).

Minimum Qualifications and Experience required

  • Degree in Life Sciences or related discipline with at least 2 years post-graduate experience within academic or industry setting, preferably including validation of novel immunotherapy targets.
  • Proven expertise in transcriptional biology techniques including RT-qPCR and RNA-seq. Additional expertise in scRNA-seq, CITE-Seq and/or Ribo-Seq is desirable.
  • Histological and molecular pathology experience including immunohistochemistry and RNAscope.
  • Experience using Python and/or R desirable.
  • Laboratory experience with mammalian cell culture desirable.
  • Experience working in cross-functional teams.
  • Excellent organisational skills and ability to monitor and track key activities.
  • Strong communication skills, both written and verbal.

Further information

The Enara Bio team is driven to make a meaningful difference for people affected by cancer. Our culture is defined by our behavioural ethos:
  • Act with unconditional positive regard and integrity
  • Support each other to grow and develop
  • Promote a collaborative, passionate and fun working environment
  • Innovate by discussing issues, data and ideas openly
  • Respect each other and value our diversity
  • Embrace our shared goals and take ownership of our journey

We offer a competitive salary, commensurate with qualifications and experience, and a benefits package including pension and health insurance.

Applicants should be able to demonstrate proof of the right to work in United Kingdom.
Enara Bio Limited is an equal opportunities employer.

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Job Reference: 440803