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(Senior) Scientist - Cell Process Development

Introduction

Enara Bio™ (formerly known as Ervaxx) is a science-led company targeting the T-cell/cancer cell interface (the “immune synapse”) to develop new targeted cancer immunotherapies designed to treat a broad patient population. Our current focus is the development of novel T-cell therapies based on complementary and proprietary insights from interrogating the immune synapse from both angles – on the tumor side, a growing set of novel tumor-specific targets; and on the T-cell side, a set of robust T-cell receptors (TCRs) with potent tumoricidal activity.

Enara Bio was founded in 2016 and has been well funded to invest in the build out and growth of our proprietary discovery platform and our fantastic team. The company has offices in London, UK and laboratories in Oxford, UK.

Job Summary

Enara Bio is expanding its CMC expertise within the organisation, to deliver a pipeline of Cell and Gene Therapy products, including autologous ex vivo gene modified TCR-T therapeutics, to patients with cancer. We are now looking for an enthusiastic lab-based scientist to join the cell process development team, on projects spanning from research through to GMP manufacturing.

The main focus of the role is to assess methods and technologies to establish robust manufacturing processes for our cell products. This will require close collaboration with the research function and other members of the process and analytical development teams. This role also has the potential opportunity to engage with external partners.

Key Responsibilities

  • Plan, conduct, and analyse experiments and interpret results, both individually and as part of a team
  • Document and record experiments in a clear and timely manner
  • Closely interact with colleagues from research and process and analytical development
  • Develop new assays, technology and protocols together with the Cell Process Development Lead
  • Actively engage in research and development project teams and provide scientific and technical expertise
  • Contribute and execute on project plans to assess novel cell process technologies and methods internally and with external partners
  • Partner with the research team to establish robust GMP compliant cell culture processes to rapidly advance next gen and new clinical candidates from the pipeline into manufacturing
  • Share knowledge and train external partners as part of tech transfers
  • Clearly communicate problems, risks and potential impact on timelines, as well as recommended solutions
  • Author, review, and keep record of protocols, manufacturing and analytical documentation and reports

Minimum Qualifications and Experience required

  • Degree in Life Sciences or related discipline
  • Relevant post-graduate experience within academic or industry setting
  • Proven experience of working to objectives and timelines
  • T-cell biology and process understanding
  • Proven laboratory experience with primary cell culture
  • Strong communicator, both written and verbal
  • Self-motivated and enthusiastic team player with strong attention to detail
  • Computer literate and ability to familiarise with different IT systems

Desirable:
  • Cell culture experience with primary human T cells at various scales
  • Experience with analytical methods to characterise T cells
  • GMP process development experience with closed and automated culture and process technology
  • Design of experiments
  • Experience working in project teams

Other:
  • Occasional travel to external partners will be required

Closing date

Until filled

Further information

The Enara Bio team is driven to make a meaningful difference for people affected by cancer. Our culture is defined by our behavioral ethos:

  • Act with unconditional positive regard and integrity
  • Support each other to grow and develop
  • Promote a collaborative, passionate and fun working environment
  • Innovate by discussing issues, data and ideas openly
  • Respect each other and value our diversity
  • Embrace our shared goals and take ownership of our journey

We offer a competitive salary, commensurate with qualifications and experience, and a benefits package including pension and health insurance.

Applicants should be able to demonstrate proof of the right to work in United Kingdom.

Enara Bio Limited is an equal opportunities employer.

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Job Reference: 383321