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Senior Scientist - Protein Biochemistry

Enara Bio’s purpose is to shine a light on unconventional T cell targets to develop cancer immunotherapies designed to provide lasting benefit for broad patient populations. Our proprietary EDAPT™ platform enables us to discover a novel and differentiated class of cancer-specific targets from the genomic dark matter, which we call Dark Antigens™. We are pioneering approaches to exploit these Dark Antigen targets with a range of immunotherapeutic modalities, including bispecific T-cell engagers, adoptive cell therapies and cancer vaccines.

Enara Bio was founded in 2016 and has been well funded to invest in the build out and growth of our R&D efforts and our fantastic team. The company is based in Oxford, UK

We are looking for a motivated Senior Scientist with a passion for immunotherapy to join our newly establish Protein Biochemistry function. This role requires deep technical expertise in in-vitro display and selection, and recombinant protein expression (bacterial and mammalian). This is an opportunity for an innovative scientist to develop novel technology platforms and discover new therapies for cancers with significant unmet need.

Key Responsibilities:
  • Designing, conducting, and evaluating experiments to advance our preclinical pipeline of bispecific T cell engagers
  • Helping to establish in-vitro display (yeast and mammalian) platforms and protocols required to engineer our TCR-directed, bispecific molecules
  • Providing scientific expertise on TCR engineering projects to generate affinity optimised TCRs
  • Recombinant protein expression in mammalian and bacterial cells and purification using an AKTA FPLC system
  • Ensuring scientific excellence is maintained within the Protein Biochemistry function
  • Reporting of experimental data at company meetings
  • Actively contributing to a vibrant and innovative working environment where improvements and new ideas are adopted and freely shared among the teams
  • Working closely with other functional teams, project & process leaders to advance our platforms and pipeline

Minimum Qualifications and Experience required:
  • A PhD or equivalent scientific experience in a relevant discipline – e.g. molecular biology, biochemistry
  • 3+ years’ experience in scientific roles preferably within biotech/pharma industry
  • Hands-on experience and deep technical knowledge of in-vitro display and panning platforms (ideally including yeast and mammalian display)
  • Hands-on experience of recombinant protein expression in bacterial and mammalian cells and purification using an AKTA system
  • Hands-on experience in molecular biology e.g. PCR, cloning, site-directed mutagenesis and sanger sequencing
  • Proven success in execution of scientific projects, demonstrating innovate thinking and problem solving
  • Excellent communications skills and a strong desire to work in a highly collaborate environment

The Enara Bio team is driven to make a meaningful difference for people affected by cancer. Our culture is defined by our behavioural ethos:
  • Act with unconditional positive regard and integrity
  • Support each other to grow and develop
  • Promote a collaborative, passionate and fun working environment
  • Innovate by discussing issues, data and ideas openly
  • Respect each other and value our diversity
  • Embrace our shared goals and take ownership of our journey

We offer a competitive salary, commensurate with qualifications and experience, and a benefits package including pension and health insurance.

Applicants should be able to demonstrate proof of the right to work in United Kingdom.
Enara Bio Limited is an equal opportunities employer.

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Job Reference: 953577