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Senior Scientist, TCR Discovery


Enara Bio’s purpose is to shine a light on unconventional T cell targets to develop cancer immunotherapies designed to provide lasting benefit for broad patient populations. Our proprietary EDAPT™ platform enables us to discover a novel and differentiated class of cancer-specific targets from the genomic dark matter, which we call Dark Antigens™. We are pioneering approaches to exploit these Dark Antigen targets with a range of immunotherapeutic modalities, including bispecific T-cell engagers, adoptive cell therapies and cancer vaccines.
Enara Bio was founded in 2016 and has been well funded to invest in the build out and growth of our R&D efforts and our fantastic team. The company is based in Oxford, UK.

Job Summary

We are looking for a Senior Scientist to join the immunology function, working within TCR Discovery, who has a strong passion for immunology and the role of T cells in the exciting field of immuno-oncology.

You will be expected to:

You will design, conduct, and supervise experiments aimed at characterising Enara Bio’s novel tumour-specific antigens, which will drive the development of therapies to make a meaningful difference for patients suffering from cancer.

Key Responsibilities

  • Design and perform experiments to isolate and characterise Dark Antigen specific TCRs. Experience in isolating immune cells using density-gradient separation, magnetic beads and flow-cytometry based sorting/analysis is required.
  • Phenotypic and functional profiling of low frequency cells e.g. ELISpot, multimer staining, etc.
  • Apply your expertise to conduct single cell RNA sequencing experiments
  • Provide expert technical direction, challenge and problem solving in projects, and contribute to setting up new experimental methodologies
  • Actively contribute to a vibrant and innovative working environment where improvements and new ideas are adopted and freely shared among teams
  • Provide scientific leadership, supervision, coaching and mentorship for less experienced scientists in your team, as well as other scientists in our matrixed environment
  • Provide functional leadership for company projects from early discovery through to candidate selection including regular updates to the company’s senior leadership team

Minimum Qualifications and Experience required

  • PhD or equivalent experience in a relevant scientific discipline, strong expertise in immunology preferred
  • Proven experience of working in T cell therapy, ideally in a biotech setting (minimum 5 years)
  • Proven experience of relevant immunological laboratory techniques and a track record of assay development
  • Interest and passion for developing scientists and sharing your knowledge and expertise
  • Previous experience of mentoring other scientists

Further information

The Enara Bio team is driven to make a meaningful difference for people affected by cancer. Our culture is defined by our behavioural ethos:
• Act with unconditional positive regard and integrity
• Support each other to grow and develop
• Promote a collaborative, passionate and fun working environment
• Innovate by discussing issues, data and ideas openly
• Respect each other and value our diversity
• Embrace our shared goals and take ownership of our journey

We offer a competitive salary, commensurate with qualifications and experience, and a benefits package including pension and health insurance.

Applicants should be able to demonstrate proof of the right to work in United Kingdom.
Enara Bio Limited is an equal opportunities employer.

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Job Reference: 1139421